ABSTRACT
In this study, we aimed to evaluate the changes in laboratory parameters of COVID-19 hospitalized patients who admitted to the intensive care unit (ICU). In this retrospective study, the confirmed cases of COVID-19 patients who were hospitalized in ward and ICU from 19 January 2020 to 27 February 2020 in Firoozgar hospital, Tehran, Iran were enrolled. We analyzed clinical characteristics and laboratory findings through medical records. SPSS v.25 was used for statistical analysis. The 70 COVID-19 patients by the mean age±std. deviation 68.37±13.29 years (range 27-93 years) were carried out. The average duration of hospitalization±std. deviation was 7.4±6.17 days (7-27 days). 43 cases were male (61.4%). Fifteen patients (21.4%) did not have any underlying disease. There was significant increasing in laboratory parameters included white blood cells (p<0.0001), Creatinine (p = 0.007), aspartate aminotransferase (AST) (p = 0.050) and alanine transaminase (ALT) (p = 0.031). However, lymphocyte count was significantly decreased during hospitalization in ward before ICU-admission (p<0.0001). There was no significant difference for platelets count (p = 0.94), lactate dehydrogenase (p = 0.36), International Normalized Ratio (INR) (p = 0.114) and Partial Thromboplastin Time (PTT) (p = 0.72). Most ICU-admitted patients presented with respiratory syndrome characteristics. ICU-admitted patients had significant increase in WBC and decrease in lymphocyte count. Evidence of failure in kidney, liver function, higher activity of the coagulation system were discovered among ICU-admitted patients.